Endocrine Abstracts

Peptide long-acting somatostatin receptor ligands (SRLs) are a first line medical treatment for acromegaly but are not efficiently absorbed when delivered orally. Years of injections with SRLs are associated with variable dose delivery, injection site reactions, and excessive life burden. Paltusotine (CRN00808) is a nonpeptide small molecule somatostatin type 2 (sst2) receptor agonist with high oral bioavailability (70%) and a 42–50 hour terminal elimination half-life in...

Transition from childhood to adulthood is a vulnerable period in all adolescents and particularly inCO-GHD patients. Low bone mineral density (BMD) and body composition alterations are frequently reported in young adults with CO-GHD, but relevant large monocentric studies are lacking.Patients and Methods: In a monocentric, observational, retrospective cross-sectional study conducted from 2005–2019, 107 CO-GHD patients were analyzed (17–26 yea...

Objective: Kisspeptin is hormone involved in the initiation and maintenance of fertility. Placenta is the major source of kisspeptin but its role during gestation is still matter of debate. Studies investigating kisspeptin levels during gestation in patients with diabetes and hypertension are lacking. Our aim was to prospectively evaluate kisspeptin levels in pregnant women with chronic diseases such as IDDM and H.Design and methods: Kisspeptin levels we...

Background: The so-called silent pituitary adenomas are a subtype of pituitary tumors showing positive immunoreactivity for one or more pituitary hormones, but without any clinical manifestations for oversecretion of these hormones. They are clinically labeled as non-functional pituitary adenomas (NFPA), some of them with particularly aggressive behavior. Rare patients might present with big plurihormonal pituitary tumors which ‘whisper’ hormones (GH or ACTH) and pro...

Hypopituitarism, in particular growth hormone (GH) deficiency, is common among survivors of traumatic brain injury (TBI). We investigated neurobehavioral consequences of TBI-induced GH deficiency (GHD) in 61 patients (aged 37.7±1.7 years, 44 male/17 female) at least one year (mean, 3.9±0.6 years) after moderate and severe TBI (mean GCS score 10.6). All patients were tested with standard neuropsychological battery (MMSE, TMT, RAVLT, RCF, BNT and WCST for executive cog...

Schizophrenia is a devastating mental illness associated with obesity and diabetes mellitus rates that far exceed those of the general population.The aim was to evaluate changes in positive energy balance (serum insulin, leptin and ghrelin) and hormones involved in neuroendocrine regulations (serum cortisol, growth hormone and prolactin) before treatment with atypical antypsyhotics (SGA) in normal weight patients with schizophrenia.<p class="abstext"...

Aim of this study was to investigate head to head ACTH and cortisol responses to DDAVP and ghrelin in patients with CD. Study was approved by the local ethics committee and informed consent obtained. Nine patients with CD were submitted to ghrelin 1 μg/kg and DDAVP 10 μg bolus iv administration on two separate occasions. Blood was sampled at 0.15, 30, 45, 60, 90 min. for ACTH (ELISA) and cortisol (RIA, Cis, Bio International, France) measurements.<p class="abstex...

Pheochromocytomas and sympathetic paragangliomas are rare catecholamine-secreting tumors and represent very rare causes of intracerebral hemorrhage in young. Few cases of these neuroendocrine tumors which presented with intracerebral hemorrhage have been reported. A 32-year-old man presented to our emergency department because of sudden onset of severe headache. He has a six months history of headache, palpitations and sweating. During examination he became somnolent and devel...

Transition from childhood to adulthood is particularly important in patients with COGHD mainly because of the associated metabolic abnormalities, inadequate body composition and decreased bone mineral density (BMD). There is a lack of large monocentric studies related to this issue.Design: Monocentric, observational, retrospective cross-sectional study.Patients: We collected 85 COGHD patients (58 males, aged 17–26 years) trans...

Long-acting somatostatin receptor ligands (LA-SRLs) are a first line medical treatment for acromegaly but require monthly parenteral administration. Paltusotine (CRN00808) is a nonpeptide, small molecule somatostatin type 2 (SST2) receptor agonist with high oral bioavailability (70%), suitable for once daily, oral dosing. The recently reported results of the ACROBAT Edge study (NCT03789656) suggest that patients with acromegaly treated with injected SRLs can switch to once dai...